Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. PDF | Eudragit RS PO microspheres containing stavudine as a model drug were prepared by the solvent evaporation method using acetone liquid paraffin. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of.
|Published (Last):||7 June 2016|
|PDF File Size:||6.37 Mb|
|ePub File Size:||9.23 Mb|
|Price:||Free* [*Free Regsitration Required]|
Drug Dev Ind Pharm. Nanoparticles present significant advantages over conventional free drug dosing [ 56 ]. Figure 2 in vitro cumulative release of metformin. Department of Pharmaceutical Technology, Smt. Materials and Methods 2. Generate a file for use with external citation management eudagit. The ammonium groups are present as salts and make the polymers permeable.
Time-controlled Drug release
It was applied to determine the significance and the magnitude of the effects of the main variable and their interactions by applying probability value value. Factors with values that are less than 0. On the basis of the results obtained from solubility study, SDS was chosen as surfactant to stabilize nanoparticles and acetone was chosen as an organic phase.
Property Data This page displays only the text of a material data sheet. The wide applications of GC and GD propose their strong hydrophobic nature, substantial binding property, compatibility with the eueragit environment [ 17 ] and their sustaining property [ 18 ]. To receive news and publication updates for Journal of Nanomaterials, enter your email address rsppo the box below.
Mean dissolution time MDT value is used to characterize drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. The optimized formulation was characterized for in vitro drug release and structural characterization.
This phenomenon may be attributed to surface erosion or initial disaggregation of the matrix tablet prior to gel layer formation around the tablet core [ 25 ]. Eudragit polymers are commercially available synthetic polymers used in drug delivery.
This can further be seen from 3D surface plots in Figure 3. Moreover, coefficient of determination indicates the proportion of variation in the data that is explained by the model.
View at Google Scholar L. The granules were evaluated for angle of repose, loose bulk density LBDtapped bulk density TBDcompressibility index and drug content. This rdpo that the drug is compatible with the polymers used in the investigation. Table 6 shows that zeta potential is significantly influenced by ratio of a polymer to a drug and sonication time. An obstacle to more successful use of metformin therapy is the high incidence of concomitant gastrointestinal symptoms, such as abdominal discomfort, nausea, and diarrhea that especially occurs during the initial period of treatment.
The completed design consisted of 15 experimental runs, which were done in triplicate. Figure 3 in vitro cumulative release of metformin. Matrix tablets, each containing mg metformin HCl were prepared by a conventional non-aqueous wet granulation technique. This can be due to the fact that an increase in polymer concentration led to an enhancement of the concentration gradient between emulsion droplets and the continuous phase, as a result increasing the amount of drug partitioning into the eudragitt phase [ 38 ].
The reduced mathematical models for mean particle size, EE, average zeta potential, and PDI are presented by 4 to 7respectively. The in vitro dissolution study was carried out using USP 22 apparatus I, paddle method and the tspo was analysed using zero order, first order, Higuchi, Korsmeyer and Hixson-Crowell equations.
Hausner’s ratio was related to interparticle friction and could be used to predict powder flow properties. The hydrophilic polymer selected for the present study was Eudragit RSPO, which provide pH-independent drug release to oral dosage forms that can be used for formulating the sustained-release edragit forms [ 14 ]. The composition of various formulations of the tablets with their codes is listed in Table 1.
Granulation was done manually with a solution of isopropyl alcohol. The equation derived for mean particle size is given in where, and are ratio of a polymer to a drug, concentration of a surfactant, and sonication time, respectively, and and are interaction effects between ratio of a polymer to a drug and sonication time, concentration of a surfactant, and sonication time while and are quadratic effect on mean particle size.
Users requiring more precise data for scientific or engineering calculations can click on the property value to see the original value as well as raw conversions to equivalent units. Further, such dense matrix, specifically when it is hydrophobic in nature, may be expected to favor less penetration of the dissolution medium in the tablets. It is a potent inhibitor of the virus nucleotide reverse transcriptase and was approved for clinical use in [ 1 ].
Hydrophilic eudragit when combined with hydrophobic GC and GD FX-FXV no burst release was observed, which may be due to the tendency to mask these quaternary ammonium groups to some extent, thereby modifying release of the drug. Infrared spectrum was taken by scanning the samples of pure drug and the polymers individually over a wave number range of to cm —1 using Fourier transform infrared spectrophotometer FT-IR, Shimadzu S, Shimadzu, Japan.
The coefficient of determination 0. The authors declare that there is no conflict of interests regarding the publication of this paper.
Small mean particle size was obtained by low polymer to a drug having ratio of 1: MatWeb is intended for personal, non-commercial use. Modified nanoprecipitation method was used to prepare 15 formulations as per BBD. The results are expressed as mean standard deviation SD. Unlike other antidiabetic drugs metformin HCl does not induce hypoglycemia at any reasonable dose, and hence it is called as an antihyperglycaemic rather than a hypoglycemic drug [ 2 ].
Small mean particle size was observed in Figure 2 b when sonication time was increased.
Journal of Nanomaterials
The natural materials have been extensively used in the field of drug delivery because they are readily available, cost-effective, eco-friendly, capable of multitude of chemical modifications, potentially degradable and compatible due to their fudragit origin [ 16 ].
It is also an important component of the fixed dose antiretroviral combinations Truvada, Atripla, and Complera [ 3 ]. The same profile was observed in Figure 3 b.
The in vitro drug release studies were carried out using dialysis bag method [ 25 ]. This finding can be attributed to the hydrophobic nature of GC and GD, which retarded drug release from the matrix.